From Clostridioides difficile to the gut microbiota: Designing therapeutic interventions for or against intestinal bacteria

Our research focuses on the design of small-molecules and natural product analogues as novel drug candidates. We are especially interested in the chemistry and biology of inositol phosphates and carbohydrates. We have developed novel strategies to inactivate the toxins responsible for the pathogenesis of Clostridioides difficile. We are also interested in the human gut microbiota and how molecules can impact its composition and metabolism, for the benefit of the host (us!).