From Clostridioides difficile to the gut microbiota: Designing therapeutic interventions for or against intestinal bacteria

Welcome to the Castagner Lab! Our team includes chemists, pharmacologists, and microbiologists who work closely together to explore new therapeutic avenues. We actively collaborate with other labs with expertise in microbiology, structural biology, computational chemistry, bioinformatics, and oncology to expand our understanding of complex biological systems. With a multidisciplinary approach, we strive to explore novel drugs and therapies that improve the lives of patients.

Our research focuses on the design of small molecules and natural product analogues, with a particular interest in inositol phosphates, carbohydrates, and polyphenols. We are notably developing novel strategies to inactivate the toxins responsible for the pathogenesis of Clostridioides difficile. We are also interested in prebiotic approaches where glycans and polyphenols can enhance the growth of beneficial bacteria in the gut and improve human health, especially in the context of cancer immunotherapy.