Publications


Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers.

Schantl, A. E.; Verhulst, A.; Neven, E.; Behets, G. J.; D’Haese, P. C.; Maillard, M.; Mordasini, D.; Phan, O.; Burnier, M.; Spaggiari, D.; Decosterd, L. A.; MacAskill, M. G.; Alcaide-Corral, C. J.; Tavares, A. A. S.; Newby, D. E.; Beindl, V. C.; Maj, R.; Labarre, A.; Hegde, C.; Castagner, B.; Ivarsson, M. E.*; Leroux, J. C.*

Nat. Commun. 202011, 721.


Drugging the gut microbiota: toward rational modulation of bacterial composition in the gut.

Altamura, F.; Maurice, C.F.; Castagner, B.*

Curr. Op. Chem. Biol. 2020, 56, 10-15.


Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy

Ivarsson, M.E.; Durantie, E.; Huberli, C.; Huwiler, S.; Hegde, C.; Friedman, J.; Altamura, F.; Lu, J.; Verdu, E.F.; Bercik, P.; Logan, S.M.; Chen, W.; Leroux, J.-C.; Castagner, B.*

Cell Chem. Biol. 201926, 17-26.


Bisso, S.; Mura, M.; Castagner, B.; Couvreur, P.; Leroux, J.-C.* “Dual delivery of nucleic acids and PEGylated-bisphosphonate via calcium phosphate nanoparticles” Eur. J. Pharm. Biopharm. 2019142, 142-152.


Huang, X.; Andina, D.; Ge, J.; Labarre, A.; Leroux, J.-C.*; Castagner, B.* “Characterization of calcium phosphate nanoparticles based on a PEGylated chelator for gene delivery” ACS Appl. Mater. Interfaces 20179, 10435.


Huang, X.; Leroux, J. C.*; Castagner, B.* “Well-Defined Multivalent Ligands for Hepatocytes Targeting via Asialoglycoprotein Receptor” Bioconjug. Chem. 201728, 283.


Moroz, E.; Lee, S.H.; Yamada, K.; Halloy, F.; Martinez-Montero,S.; Jahns, H.; Hall, J.; Damha, M.J.; Castagner, B.; Leroux, J.-C.* “Carrier-free Gene Silencing by Amphiphilic Nucleic Acid Conjugates in Differentiated Intestinal Cells” Mol. Ther. Nucl. Acids 20165, e364.


Durantie, E.; Huwiler S.; Leroux, J.-C.; Castagner, B.* “A new chiral phosphoramidite reagent for the synthesis of inositol phosphates” Org. Lett. 201618, 3162-3165.


Sun, T.; Morger, A.; Castagner, B.*; Leroux, J.-C.* “An oral redox-sensitive self-immolating prodrug strategy” Chem. Comm. 201551, 5721-5724.


Durantie, E.; Leroux, J.C.; Castagner, B.* “New Paradigms for the Chiral Synthesis of Inositol Phosphates” ChemBioChem 201516, 1030-1032. 


Ivarsson, M.E.; Leroux, J.C.; Castagner, B.* “Investigational New Treatments for Clostridium difficile Infection” Drug Discov. Today 201520, 602-608.


Lee, S.H.; Moroz, E.; Castagner B.*; Leroux, J.-C.* “Activatable Cell Penetrating Peptide–Peptide Nucleic Acid Conjugate via Reduction of Azobenzene PEG Chains” J. Am. Chem. Soc. 2014136, 12868-12871.


Fuhrmann, K.; Połomska, A.; Aeberli, C.; Castagner, B.; Gauthier, M. A.; Leroux, J.-C. “Modular design of redox-responsive stabilizers for nanocrystals” ACS Nano 20137, 8243-8250.


Giger, E. V.; Castagner, B.; Räikkönen, J.; Mönkkönen, J.; Leroux, J.-C. “siRNA transfection with calcium phosphate nanoparticles stabilized with PEGylated chelators” Adv. Healthcare Mat20132, 134-144.


Adamo, R.; Nilo, A.; Castagner, B.; Boutureira, O.; Berti, F.; Bernardes, G. J. L. “Synthetically defined glycoprotein vaccines: Current status & future directions” Chem. Sci. 20134, 2995-3008. 


Lee S. H.; Castagner B.*; Leroux, J.-C.* “Is there a future for cell penetrating peptides in nucleic acid delivery?” Eur. J. Pharm. Biopharm201385, 5-11.


Giger, E. V.; Castagner, B.; Leroux, J.-C. “Biomedical applications of bisphosphonates” J. Control. Release 2013,167, 175-188.


Esposito, D.; Hurevich, M.; Castagner, B.; Wang, C.-C.; Seeberger, P. H. “Automated synthesis of sialylated oligosaccharides” Beilstein J. Org. Chem. 20128, 1601-1609.


Felber, A. E.; Bayó-Puxan, N.; Castagner, B.; Deleavey, G. F.; Damha, M. J.; Leroux, J.-C. “The interactions of amphiphilic antisense oligonucleotides with serum proteins and their effects on in vitro silencing activity” Biomaterials 201233, 5955-5965.


Kröck, L.; Esposito, D.; Castagner, B.; Wang, C.-C.; Bindschädler, P.; Seeberger, P. H. “Streamlined Access to Conjugation-Ready Glycan by Automated Synthesis” Chem. Sci. 20123, 1617-1622.


Zhu, B.; Trikudanathan, S.; Zozulya, A. L.; Sandoval-Garcia, C.; Kennedy, J. K.; Atochina, O.; Norberg, T.; Castagner, B.; Seeberger, P.; Fabry, Z.; Harn, D.; Khoury, S. J.; Guleria, I. “Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis” Clin. Immunol. 2012142, 351-361.


Ivarsson, M. E.; Leroux, J.-C.; Castagner, B.* Targeting Bacterial Toxins” Angew. Chem. Int. Ed. 2012, 51, 4024-4045.


Felber, A. E.; Castagner, B.; Elsabahy, M.; Deleavey, G. F.; Damha, M. J.; Leroux, J.-C. “siRNA nanocarriers based on methacrylic acid copolymers” J. Control. Release 2011152, 159-167.


Giger, E. V.; Puigmartí-Luis, J.; Schlatter, R.; Castagner, B.; Dittrich, P. S.; Leroux, J.-C. “Gene Delivery with Bisphosphonate-stabilized Calcium Phosphate Nanoparticles” J. Control. Release 2011150, 87-93.


Bayó-Puxan, N.; Dufresne, M.-H.; Felber, A. E.; Castagner, B.; Leroux, J.-C. “Preparation of polyion complex micelles from poly(ethylene glycol)-block-polyions” J. Control. Release 2011156, 118-127.


Bernardes, G. J. L.; Castagner, B.; Seeberger, P. H. “Combined Approaches to the Synthesis and Study of Glycoproteins” ACS Chem. Biol. 20094, 703-713.


Liu, X.; Wada, R.; Boonyarattanakalin, S.; Castagner, B.; Seeberger, P. H. “Automated Synthesis of Lipomannan Backbone α(1-6) Oligomannosides via Glycosyl Phosphate: Glycosyl Tricyclic Orthoester Revisited” Chem. Comm. 200830, 3510-3512.


Codée, J. D. C.; Kröck, L.; Castagner, B.; Seeberger, P. H. “Automated Solid-Phase Synthesis of Protected Oligosaccharides Containing β-Mannosidic Linkages” Chemistry – A Eur. J. 200814, 3987-3994.


Hanashima, S.; Castagner, B.; Esposito, D.; Nokami, T.; Seeberger P. H. “α(2-3)Sialylation with Galactal Acceptor and Synthesis of Sialyl Lewis X Antigen” Org. Lett. 20079, 1777-1779.


Werz, D. B.; Castagner, B.; Seeberger, P. H. “Automated Synthesis of the Tumor-Associated Carbohydrate Antigens Gb-3 and Globo-H: Incorporation of α-Galactosidic Linkages” J. Am. Chem. Soc. 2007129, 2770-2771.


Castagner, B.; Leighton, J. L. “A Modified Approach to the Phomoidrides: Synthesis of a Late-Stage Intermediate Containing a Key Carbon Quaternary Stereocenter” Tetrahedron 200763, 5895-5902.


Castagner, B.; Lacombe, P.; Ruel, R. “Samarium(II) Iodide-Mediated Synthesis of Chlorohydrins J. Org. Chem. 199863, 4551-4553.


Lacombe, P.; Castagner, B.; Gareau, Y.; Ruel, R. “Reduction of Olefins on Solid Support Using Diimide” Tetrahedron Lett. 199839, 6785-6786.